Is Modafinil tablet Safe to Use During Pregnancy?

Is Modafinil tablet Safe to Use During Pregnancy?

The narcolepsy medicines Modafinil 200 mg (Provigil Australia) and Armodafinil (Nuvigil) are associated with major congenital malformations in the Provigil/Nuvigil Pregnancy Registry, according to a study by Sigel Kaplan and colleagues.

The FDA classifies Modafinil and Armodafinil as pregnancy category C, meaning the drugs pose a risk to an unborn baby. Women should use reliable methods of birth control during treatment and for 2 months afterward.


If you have narcolepsy, your body is unable to get the sleep it needs. This may cause problems with your concentration, memory, and ability to focus. It also causes daytime sleepiness and can affect how you drive. People with narcolepsy have low levels of a chemical in the brain called hypocretin (hi-poi-KREE-tin). This is what controls your alertness.

Most narcolepsy patients are prescribed Modafinil to help manage their symptoms. Some of the most common side effects include vivid sleep-related hallucinations, such as seeing someone or something in your room that is not there. These usually occur while falling asleep or just after waking up. They can also cause feelings of fear or dread. These hallucinations may involve your senses of sight, sound, touch, or taste.

Other possible side effects of the medication are dizziness, headaches, anxiety, and stomach irritation. It is important to tell your doctor if you have any of these symptoms. The risk of these side effects is higher if you take large doses or for extended periods of time.

Some studies have linked the use of Modafinil in early pregnancy to an increased risk of birth defects, particularly heart defects and hypospadias. However, other studies have not shown an increase in the number of birth defects or other complications.

The marketing authorization holder for Modafinil with the brand names Provigil and Nuvigil has issued a DHPC, which is a letter sent to healthcare professionals warning of the potential risks for the fetus when pregnant women take the drug in the first trimester. The advice is based on data from the US Provigil/Nuvigil Pregnancy Registry and spontaneous case reports of Modafinil use in pregnancy.

Earlier this year, a study from Norway and Sweden found no evidence that Modafinil increases the risk of major congenital malformations in babies. The researchers examined nationwide medical birth registers from both countries and included all singleton pregnancies. They compared the results of those who took Modafinil in the first trimester to those who did not take the medicine.

Other medications that boost liver enzyme activity are also known to reduce the effectiveness of hormonal birth control, such as condoms and oral contraceptives. Therefore, it is important to discuss any plans to become pregnant or to conceive with your healthcare provider before you start taking any medications. They can find the best birth control method for you and provide you with alternatives to hormonal birth control if necessary.

Obstructive sleep apnea

Obstructive sleep apnea is a common condition that affects millions of people around the world. It is caused by a narrowing of the throat, and it causes breathing to stop for a short period of time while you are asleep. This can result in low blood oxygen levels, and it can lead to high blood pressure. It also increases your risk of heart and circulatory problems, including stroke. It can cause you to feel tired throughout the day, and it can also make you more likely to fall asleep while driving or working at dangerous jobs.

The symptoms of obstructive sleep apnea include snoring, gasping, or choking sounds during sleep. You may wake up with the feeling of being unsteady or lightheaded. Your partner might notice that you seem to stop breathing for a brief period during the night. Obstructive sleep apnea can also lead to headaches, a dry mouth, and dry eyes. It can also increase your risk of depression and obesity.

It is possible to diagnose obstructive sleep apnea with an overnight sleep study, or polysomnography. This test involves wearing several monitors, which measure things like your brain waves, eye movements, heart rate, and pulse oximetry. It will also evaluate your upper airway by using visualization and X-rays, which can detect an enlarged tonsil or adenoid. If you are diagnosed with obstructive sleep apnea, your doctor can prescribe buy Modalert 200 medication or suggest other treatments to help you get better sleep.

Health Canada warned pregnant women to avoid Modafinil in February 2019. The warning was based on preliminary data from the U.S. Nuvigil/Provigil Pregnancy Registry, which identified a higher incidence of birth defects in babies born to mothers who took the drug. The warning included a statement that the risks outweighed the benefits of the medication in pregnant women.

If you take Modafinil and decide to become pregnant, talk to your healthcare provider about continuing the treatment. You should only continue taking the drug if it is important to you, and your doctor will be able to assess the risk versus benefit for you.

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